Multifunctional plasmonic gold nanostars for cancer therapeutic and diagnostic applications
Wrenit Gem Pearl Irudayaraj1*, Elena V. Perevedentseva1,2, Artashes V. Karmenyan1, Vitaly A. Khanadeev3, Nikolai G. Khlebtsov3,4, Chia-Liang Cheng1
1Physics, National Dong Hwa University, Hualien County, Taiwan
2Physics, P. N. Lebedev Physics Institute, Moscow, Russian Federation
3Lifescienece, Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov, Russian Federation
4Physics, Saratov National Research State Universit, Saratov, Russian Federation
* Presenter:Wrenit Gem Pearl Irudayaraj,
Gold nanostars particles (AuNSts) have gained great attention in cancer therapy and bio-imaging due to enhanced and tunable localized surface plasmon resonance across visible-near infrared range. This makes them a potential candidate for nanotheranostics. Two types of AuNSts having plasmonic absorption peaks at 600 and 750 nm wavelength were chosen and compared for this study. Both AuNSts exhibited excellent biocompatibility towards A549 cells (human lung cancerous cell line). To demonstrate AuNSts imaging ability, the treated cells were observed using fluorescence lifetime imaging (FLIM) with two-photon excitation. Strong fluorescence at two-photon excitation was observed for both kinds of AuNSts. Benefiting from the tip-enhanced plasmonic properties, AuNSts trigger a photothermal therapy with high efficiency under the irradiation of NIR (Near Infrared) light to increase the temperature, which induce the cell death. Therefore, AuNSts having wide range of plasmonic properties are promising agent for cancer nanotheranostics.

Keywords: Gold nanostars, Plasmonic resonance, Nanotheranostics, Two-photon fluorescence, Photothermal therapy